SYSTEMS BIOLOGY PH.D STUDENTSHIP 2011 – UNIVERSITY OF EXETER

Systems biology is an emerging field that combines mathematical analysis, engineering approaches and cutting-edge biological data generation to better understand biological systems. This system-level understanding ties closely to our ability in developing new medicines and biotechnologies. Biological systems are inherently complex and are a result of evolution. Understanding these systems requires us to draw on mathematical modelling, systems dynamics analysis and in silico simulations of agent-based model systems. In this project, we will utilise these approaches to understand the cellular metabolic networks of bacteria and to design them de novo. Nature has an immense capacity to produce useful metabolites from simple building blocks. Even “simple” single celled organisms can use a handful of basic molecules, available to them in the environment, to make an array of diverse compounds. These are then utilised as energy source, molecular signals or even as toxins. Humans use such compounds in their diet, as medicines or in industrial applications. As such, it is of immediate value to understand the structure and dynamics of metabolic networks responsible for the production of diverse metabolites. Our analysis will combine approaches from graph theory, control theory and evolutionary biology to achieve such an understanding. We will then use the insight to manipulate existing metabolic networks in order to increase yield of specific products, or to design entirely novel networks.

Application Criteria : The successful applicant should have or expect to achieve at least an upper second class Honours degree, or equivalent qualifications, with either a mathematical, physical, or biochemical focus. Experience in graph theory, systems dynamics and computer programming would be beneficial. Candidates are expected to have a genuine interest in biology/evolution and to be motivated in expanding their skill set and working at the interface of biology and computational/mathematical biology.

Funded By : College of Engineering, Mathematics and Physical Sciences

Application Deadline : 14th March 2011

Number of Awards : 1

Value : Three-year studentship: Tuition fees [UK/EU or International] and an annual maintenance allowance at current research council rate

Duration of Award : Per Year

How to Apply : To Apply, you must complete the online web form (http://www.exeter.ac.uk/postgraduate/money/studentships/application/). You will be asked to submit some personal details and upload a full CV, covering letter and details of two academic referees. Your covering letter should outline your academic interests, prior research experience and reasons for wishing to undertake this project.

Contact :
University of Exeter
Streatham Campus
Northcote House
Exeter EX4 4QJ

Email : E.G.Roberts(AT)exeter.ac.uk

Contact Number : +44 (0) 1392 661000

Source : http://www.exeter.ac.uk/studying/funding/award/?id=637